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After being taken back from the orphanage, Yvette Jones longed for familial love, but due to her parents' and siblings' bias and prejudice, she was neglected and isolated at home, leading to a stomach illness. Her foster sister Sienna replaced her medication with vitamins, causing Yvette's condition to deteriorate into stomach cancer, while the family believed Sienna and thought Yvette was pretending to have a terminal illness just to gain sympathy. Ultimately, Yvette was framed by Sienna, kicked out of the house, and brutally killed. In her last moments, she met Jared, the only person who extended a helping hand to her in this life. In her second life, Yvette quickly severed ties with her family and focused on herself. To repay Jared for his help in her previous life, Yvette utilized her advantages from her previous life and her own talents to create a medical company with Jared and her friend, ultimately swallowing the Jones family business and making Sienna pay for her misdeeds. In the end, Yvette successfully avenged herself and lived a happy life with Jared.

Anna Poole had faced hardships since childhood. While trying to resolve a company crisis with her good friend, Serene Cox, Anna was drugged and sold to Mr. King. After Anna injured Mr. King and escaped, she ended up in the room of another man, Zach Howl, who was also under the influence of an aphrodisiac. As a result, they unexpectedly became intimate. As soon as Anna regained consciousness, she decided to confront Serene and accidentally overheard a conspiracy between Serene and the supposedly deceased Bryan Lane. Outraged, Anna confronted Serene, who injured her and caused a fire to start. In a life-threatening situation, Anna was saved by Waver Taylor, who had just returned to the country. Ten months later, she gave birth to twins, and one of them was taken away by the Browns. Along with a doctor, the Brown mother and daughter falsely claimed that the child died to suffocation.

Leon Johnson had been working when he suddenly collapsed. After being diagnosed with cancer and given only three months to live, he decided to keep the diagnosis a secret from his wife, Rachel, not wanting to burden her. That evening, Rachel insisted he accompany investors for a drinking session that left him vomiting blood. Despite his condition, Rachel was constantly defending her first love, Yosef Lloyd. Leon managed to land a major contract and, excited about his success, rushed home, only to find Rachel feeding Yosef porridge, which sparked a heated argument. When Leon vented his frustrations to Rachel, she stormed out and climbed into a car with the drunk Yosef. In a tragic accident, Yosef crashed the car and killed Rachel's mother. Leon took his mother-in-law to the hospital, but the delay in getting there led to her death. The loss of his mother-in-law, who had always treated him like a son, hit Leon hard. But when he revealed the truth to Rachel, the wife he had once loved deeply refused to believe him, accusing him of lying.

Clare was the woman Axel begged and coaxed for—writing 99 love letters—before finally winning her hand in marriage. By their fifth year,however, Axel grew restless and began spending time with a young nurse. The girl, Emma, came from a poor family yet carried herself with quiet pride. When she firmly rejected the black card Axel offered,declaring she would never be anyone's kept woman, he became obsessed. Axel started appearing around Emma more and more,drawing the attention of all their friends, while briefly forgetting the wife he had once courted with 99 heartfelt letters. Clare neither cried nor argued. Instead, each time Axel broke her heart, she burned one of those letters. And when the last of the 99 was reduced to ashes, it would mark the day she left him for good.